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SYNVISC® One is only intended for intra-articular use by a physician to treat pain associated with osteoarthritis of the knee. Hylan G-F 20 is a sterile, nonpyrogenic, elastoviscous fluid containing hylan A and hylan B polymers produced from a highly purified avian extract. Hylans are derivatives of hyaluronan (sodium salt of hyaluronic acid) and consist of repeating disaccharide units of N-acetylglucosamine and sodium glucuronate. Hylan A has an average molecular weight of approximately 6,000,000 daltons and hylan B is a hydrated gel. Hylan G-F 20 contains hylan A and hylan B in a buffered physiological sodium chloride solution.
Hylan G-F 20 is biologically similar to hyaluronan. Hyaluronan is a component of synovial fluid which is responsible for its elastoviscosity. The mechanical (elastoviscous) properties of hylan G-F20 are, however, superior to those of synovial fluid and hyaluronan solutions of comparable concentration. Hylan G-F 20 has an elasticity (storage modulus G’) at 2.5 Hz of 111 and 13 Pascals (Pa) and a viscosity (loss modulus G’’) of 25 and 2 Pa. Elasicity and viscosity of knee synovial flud of 18 to 27 year old humans measured with comparable method at 2.5 Hz are G’ = 117 and 13 Pa, and G’’ = 25 and 8 Pa. Hylans are degraded in the body by the same pathway as hyaluronan, and breakdown products are nontoxic.
What are benefits of SYNVISC® One?
•Supplements the knee joint fluid.
•Improves the knee joint’s natural shock absorbing abilities.
•Treatment areas: knee.
•1 x 6ml sterile pre-filled syringe.
How long does the result last for?
Treatment effects and duration depends on the degree of correction required and the individual’s lifestyle, age and skin type.
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