SYNVISC® Hylan G-F 20 is a sterile, nonpyrogenic, elastoviscous fluid containing hylan A and hylan B polymers produced from a highly purified avian extract. Hylans are derivatives of hyaluronan (sodium salt of hyaluronic acid) and consists of repeating disaccharide units of N-acetylglucosamine and sodium glucuronate. Hylan A has an average molecular weight of approximately 6,000,000 daltons and hylan B is a hydrated gel. Hylan G-F 20 contains hylan A and hylan B in a buffered physiological sodium chloride solution.
Synvisc Hylan G-F 20 Characteristics
Hylan G-F 20 is biologically similar to hyaluronan. Hyaluronan is a component of synovial fluid which is responsible for its elastoviscosity. The mechanical (elastoviscous) properties of hylan G-F20 are, however, superior to those of synovial fluid and hyaluronan solutions of comparable concentration. Hylan G-F 20 has an elasticity (storage modulus G’) at 2.5 Hz of 111 and 13 Pascals (Pa) and a viscosity (loss modulus G’’) of 25 and 2 Pa. Elasicity and viscosity of knee synovial flud of 18 to 27 year old humans measured with comparable method at 2.5 Hz are G’ = 117 and 13 Pa, and G’’ = 25 and 8 Pa. Hylans are degraded in the body by the same pathway as hyaluronan, and breakdown products are nontoxic.
Benefits of SYNVISC® Hylan G-F 20
•Supplements the knee joint fluid
•Improves the knee joint’s natural shock absorbing abilities
•Treatment areas: knee, hip, ankle, shoulder
Packaging of Synvisc Hylan G-F 20
•3 x 2ml sterile pre-filled syringe
How long does the result last for?
Treatment effects and duration depends on the degree of correction required and the individual’s lifestyle, age and skin type.
Pellentesque posuere orci lobortis scelerisque blandit.
Donec id tellus lacinia an, tincidunt risus ac